Statistical Analysis of Clinical Variants of Wilson Disease Among Males and Females in Local Population of Wah Cantt, Pakistan

The study aimed to identify the clinical variables of Wilson's disease (WD) among males and females in the local population. Wilson disease is an autosomal recessive inherited disorder that causes copper (Cu) accumulation in the body's liver, brain, and other vital organs. This research is being conducted to check the association of various symptoms of WD among males and females. A sample of 49 patients was obtained from different hospitals in Wah Cantt, Punjab, Pakistan. Among those, 29 were male and 20 were female. Frequency and percentage were computed for qualitative variables, while we used the mean and standard deviation to describe quantitative variables. The chi-square technique was used to check the significance of clinical variants of Wilson's disease among males and females. Maximum respondents, ages ranging from 16 to 20 years, were categorized into intervals. Among females, the frequency percentage was greater than that of males. In the population where parental cousin marriage (PCM) existed, there was a lower frequency percentage compared to those where consanguinity didn't exist, and the calculated p-value demonstrates that the results are significant at the 1% level. Yellow sclera had a higher frequency percentage in males than females, so the calculated p-value indicated that the results were significant at the 1% level. The prevalence of chronic liver disease was higher in men as compared to women. The calculated p-value indicated that the results are significant at 5%. Antinuclear antibodies don't exist among males and females, and the computed p-value indicated that they don't exist. The Keyser-Fischer (KF) ring presence was observed in a higher ratio in females than males, and the calculated p-value suggested that a relationship does not exist. The percentage of the absence of the symptom Spider Nivai was 100% among males and females, as it is not as recurring in Wilson's disease.